Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 4/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.32 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.32 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.32 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.32 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.32 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.32 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.32 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
| ▸ | PDE9A | O76083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885522 | 0.82 | PDE2A (0.45) | PDE2ACYP2D6PDE9A | |
| SCHEMBL957022 | 0.79 | PDE2A (1.00) | PDE2ACYP2D6PIKFYVEMAP3K14TTBK1 | |
| SCHEMBL2680484 | 0.70 | PDE2A (0.85) | PDE2APIKFYVEMAP3K14TTBK1PAK4 | |
| SCHEMBL6346581 | 0.65 | PDE2A (0.53) | PDE2ACYP2D6IDH1 | |
| SCHEMBL6345622 | 0.64 | PDE2A (0.75) | PDE2ACYP2D6 | |
| SCHEMBL962565 | 0.58 | PDE2A (0.77) | PDE2ACYP2D6PDE9A | |
| SCHEMBL2680415 | 0.58 | PDE2A (0.66) | PDE2APIKFYVEMAP3K14TTBK1PAK4 | |
| Propionic Acid SCHEMBL4162291 | 0.56 | PDE2A (0.39) | PDE2APIKFYVEMAP3K14TTBK1PAK4 | |
| SCHEMBL9214507 | 0.56 | ACACB (0.50) | ACACB | |
| SCHEMBL6349695 | 0.56 | PDE2A (0.52) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011011312-A1 | QUINOLINONE PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-01-27 | — | — | WO | disclosed |