Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.38 |
| ▸ | PIKFYVE | Q9Y2I7 | 6/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.35 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.35 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.35 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4160296 | 0.86 | GRM5 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4160262 | 0.84 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4165408 | 0.83 | GABRA1 (0.39) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4155568 | 0.82 | PIM1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4159523 | 0.79 | FFAR1 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4155220 | 0.78 | FASN (0.41) | — | |
| Propionic Acid SCHEMBL4162421 | 0.78 | KDM4E (0.40) | GABRA1PTGESTBXAS1 | |
| Propionic Acid SCHEMBL4160624 | 0.77 | MPO (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| Propionic Acid SCHEMBL4165125 | 0.77 | PARP1 (0.47) | — | |
| Propionic Acid SCHEMBL4169911 | 0.77 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | claimed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | claimed |
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | PDE2A 983/4885GABRA1 3395/4885GABRG2 2327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.