Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 15/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179246 | 0.90 | HTR6 (0.55) | HTTHTR6LMNAF2PRSS1 | |
| SCHEMBL7998160 | 0.90 | HTR6 (0.55) | HTTHTR6LMNAF2PRSS1 | |
| SCHEMBL1179248 | 0.90 | HTR6 (0.55) | HTTHTR6LMNAF2PRSS1 | |
| SCHEMBL12886467 | 0.88 | HTR6 (0.45) | HTTHTR6 | |
| SCHEMBL15334690 | 0.84 | HTR6 (0.47) | HTTHTR6KMT2AF2PRSS1 | |
| SCHEMBL8000280 | 0.82 | HTR6 (0.48) | HTR6 | |
| SCHEMBL1179071 | 0.82 | HTR6 (0.48) | HTR6 | |
| SCHEMBL1178901 | 0.79 | CNR1 (0.38) | HTR6LMNA | |
| SCHEMBL15334691 | 0.79 | HTR6 (0.54) | HTR6 | |
| SCHEMBL15334695 | 0.78 | HTR6 (0.54) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092226-A1 | SYNTHESIS OF SUBSTITUTED PYRAZOLINE CARBOXAMIDINE DERIVATIVES | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2011-08-04 | — | — | WO | disclosed |