Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 8/20 | 0.62 |
| ▸ | REN | P00797 | 4/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ECE1 | P42892 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889505 | 0.93 | HRAS (0.65) | HRASRENFNTAFNTBMME | |
| SCHEMBL6890309 | 0.90 | HRAS (0.63) | HRASRENFNTAFNTBMME | |
| SCHEMBL6885355 | 0.89 | HRAS (0.62) | HRASRENFNTAFNTBMME | |
| SCHEMBL7949405 | 0.88 | HRAS (0.65) | HRASRENFNTAFNTBMME | |
| SCHEMBL7654355 | 0.83 | HRAS (0.65) | HRASRENFNTAFNTBMME | |
| SCHEMBL7654359 | 0.83 | HRAS (0.65) | HRASRENFNTAFNTBMME | |
| SCHEMBL7654347 | 0.83 | HRAS (0.65) | HRASRENFNTAFNTBMME | |
| SCHEMBL27550462 | 0.81 | HRAS (0.61) | HRASMMP3FNTAFNTBMME | |
| SCHEMBL6888949 | 0.81 | HRAS (0.49) | HRASREN | |
| SCHEMBL6891485 | 0.80 | NMBR (0.49) | HRASCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998046625-A1 | DIPEPTIDE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1998-10-22 | — | — | WO | claimed |
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |