Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 8/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6889505 | 0.87 | HRAS (0.65) | HRASREN | |
| SCHEMBL6890309 | 0.84 | HRAS (0.63) | HRASREN | |
| SCHEMBL6885355 | 0.83 | HRAS (0.62) | HRASREN | |
| SCHEMBL7949405 | 0.83 | HRAS (0.65) | HRASREN | |
| SCHEMBL6885356 | 0.81 | HRAS (0.62) | HRASREN | |
| SCHEMBL7648657 | 0.79 | HRAS (0.68) | HRAS | |
| SCHEMBL6889788 | 0.78 | HRAS (0.51) | HRASREN | |
| SCHEMBL6889791 | 0.73 | HRAS (0.48) | HRAS | |
| SCHEMBL7655420 | 0.72 | HRAS (0.67) | HRAS | |
| SCHEMBL27550462 | 0.71 | HRAS (0.61) | HRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998046625-A1 | DIPEPTIDE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1998-10-22 | — | — | WO | claimed |
| US-6737410-B1 | SMOOTH MUSCLE ANTIPROLIFERATION AGENTS; SUCH AS 1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-METHYL-CARBAMOYL)-2 -(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2004-05-18 | — | — | US | disclosed |
| US-6265382-B1 | E.G., (S--(R*, R*))-(1-((2-(4-BENZYLOXY-PHENYL)-1-PHENETHYLCARBAMOYL-ETHYL)-M ETHYL-CARBAM OYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMIC ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-07-24 | — | — | US | disclosed |
| WO-1998046625-A1 | DIPEPTIDE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |