Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 8/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 6/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL686903 | 0.94 | SLC22A12 (0.40) | PTGER3SLC22A12CYP1A2CNR2ITGB1 | |
| SCHEMBL688053 | 0.93 | PTGER3 (0.43) | PTGER3SLC22A12CNR2ALDH1A1KDM4E | |
| SCHEMBL688284 | 0.92 | PTGER3 (0.43) | PTGER3SLC22A12CNR2ITGB1ITGA4 | |
| SCHEMBL29371834 | 0.92 | PTGER3 (0.44) | PTGER3SLC22A12CNR2 | |
| SCHEMBL686896 | 0.92 | PTGER3 (0.44) | PTGER3SLC22A12CNR2 | |
| SCHEMBL687923 | 0.92 | PTGER3 (0.41) | PTGER3SLC22A12CNR2ITGB1ITGA4 | |
| SCHEMBL686842 | 0.89 | PTGER3 (0.45) | PTGER3SLC22A12CNR2ITGB1ITGA4 | |
| SCHEMBL686997 | 0.89 | PTGER3 (0.39) | PTGER3SLC22A12CNR2FPR2ALDH1A1 | |
| SCHEMBL688170 | 0.89 | PTGER3 (0.41) | PTGER3SLC22A12CNR2ITGB1ITGA4 | |
| SCHEMBL687977 | 0.89 | ITGB1 (0.41) | PTGER3SLC22A12CNR2ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-1203766-A2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-05-08 | — | — | EP | disclosed |