Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 18/20 | 0.59 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22131767 | 0.86 | ACACB (0.55) | ACACBALOX5APFEN1MAPTCASP1 | |
| SCHEMBL1644672 | 0.81 | ACACB (0.44) | ACACB | |
| SCHEMBL6886365 | 0.77 | NPC1 (0.40) | ACACB | |
| SCHEMBL6884873 | 0.77 | NPC1 (0.40) | ACACB | |
| SCHEMBL18026947 | 0.75 | ACACB (1.00) | ACACB | |
| SCHEMBL6885718 | 0.73 | ADORA1 (0.47) | ALOX5APFEN1 | |
| SCHEMBL22131579 | 0.69 | ACACB (0.55) | ACACBMAPTCASP1 | |
| SCHEMBL22131929 | 0.69 | ACACB (0.55) | ACACBALOX5APFEN1 | |
| SCHEMBL31087500 | 0.68 | ACACB (0.38) | ACACBALOX5APFEN1 | |
| SCHEMBL1644676 | 0.68 | DHODH (0.35) | ACACBALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389536-B2 | Positive allosteric modulators (PAM) | HOFFMANN-LA ROCHE INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20110098313-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | HOFFMANN-LA ROCHE, INC. | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098313-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | GRM5, GRM1, GRM2 | ACACB 4012/4885ALOX5AP 1201/4885FEN1 4536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.