Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.78 |
| ▸ | MAPT | P10636 | 11/20 | 0.78 |
| ▸ | POLB | P06746 | 8/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.78 |
| ▸ | RECQL | P46063 | 3/20 | 0.78 |
| ▸ | THRB | P10828 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887140 | 1.00 | MEN1 (0.78) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6885682 | 0.92 | MAPT (0.66) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6885684 | 0.92 | MAPT (0.66) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6883777 | 0.89 | MAPT (0.62) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6879163 | 0.87 | POLB (0.68) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6879167 | 0.87 | POLB (0.68) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6884679 | 0.85 | POLB (0.56) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6884675 | 0.85 | POLB (0.56) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6888325 | 0.84 | ADAMTS5 (0.76) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL6888323 | 0.84 | ADAMTS5 (0.76) | MEN1KMT2AMAPTPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673816-B1 | Rhodanine carboxylic acid derivatives for the treatment and prevention of metabolic bone disorders | Esswein, Angelika (DE) | 2004-01-06 | — | — | US | disclosed |
| EP-1117655-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | Esswein, Angelika (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018747-A1 | RHODANINE CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |