Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 12/20 | 0.36 |
| ▸ | CTRC | Q99895 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886819 | 0.85 | F2 (0.39) | F2PRSS1ACECMA1CTRC | |
| SCHEMBL2235961 | 0.84 | ALDH1A1 (0.39) | ACEMEN1KMT2A | |
| SCHEMBL3058638 | 0.84 | ALDH1A1 (0.39) | ACEMEN1KMT2A | |
| SCHEMBL2240642 | 0.82 | GSTP1 (0.42) | MEN1KMT2A | |
| SCHEMBL3059904 | 0.81 | ACE (0.33) | F2PRSS1ACE | |
| SCHEMBL3059735 | 0.81 | MCL1 (0.33) | F2PRSS1ACEKLK5 | |
| SCHEMBL6887062 | 0.78 | F2 (0.39) | F2PRSS1ACECMA1CTRC | |
| SCHEMBL6887209 | 0.77 | F2 (0.40) | F2PRSS1ACECMA1CTRC | |
| SCHEMBL1052027 | 0.77 | ALDH1A1 (0.41) | ACEMEN1KMT2A | |
| SCHEMBL1052024 | 0.77 | ALDH1A1 (0.41) | ACEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002808-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2009082701-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-07-02 | — | — | WO | disclosed |