Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188720 | 0.89 | CCR2 (0.64) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL4190551 | 0.83 | CCR2 (0.82) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL13653320 | 0.83 | CCR2 (0.62) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL10143420 | 0.82 | CCR2 (0.57) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL16756206 | 0.81 | HDAC1 (0.62) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL4183327 | 0.80 | CCR2 (0.65) | CCR2CA2HDAC1MCL1GHSR | |
| SCHEMBL4190620 | 0.80 | CCR2 (0.58) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL4195330 | 0.80 | CCR2 (0.58) | CCR2CA2HDAC1MCL1KIT | |
| SCHEMBL2689511 | 0.79 | CCR2 (0.54) | CCR2CA2HDAC1MCL1MEN1 | |
| SCHEMBL13653288 | 0.77 | CCR2 (0.59) | CCR2CA2MCL1HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011022207-A1 | BIS-SULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | HIGH POINT PHARMACEUTICALS, LLC (US) | 2011-02-24 | — | — | WO | disclosed |