Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.42 |
| ▸ | CTSD | P07339 | 7/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL930703 | 0.87 | BACE1 (0.34) | BACE1CTSDBACE2DPP4KCNH2 | |
| SCHEMBL931248 | 0.84 | BACE1 (0.53) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL6886273 | 0.84 | BACE1 (0.42) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL6887086 | 0.77 | BACE1 (0.37) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL3356793 | 0.76 | BACE1 (0.44) | BACE1CTSDBACE2REN | |
| SCHEMBL7939980 | 0.76 | BACE1 (0.44) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL3357414 | 0.73 | BACE1 (0.54) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL6885096 | 0.72 | BACE1 (0.51) | BACE1CTSDBACE2RENKCNH2 | |
| SCHEMBL931305 | 0.67 | BACE1 (0.54) | BACE1BACE2KCNH2APP | |
| SCHEMBL930773 | 0.66 | BACE1 (0.39) | BACE1CTSDBACE2RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002409-A1 | 5H-PYRROLO[3,4-£>]PYRAZIN-7-AMINE DERIVATIVES INHIBITORS OF BETA-SECRETASE | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |