Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13108499 | 0.95 | MAPT (0.51) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL2462404 | 0.95 | MAPT (0.51) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL2459768 | 0.87 | MAPT (0.41) | MAPT | |
| SCHEMBL2459776 | 0.87 | MAPT (0.41) | MAPT | |
| SCHEMBL2463515 | 0.87 | MAPT (0.41) | MAPT | |
| SCHEMBL6890803 | 0.85 | SIRT6 (0.46) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL11905342 | 0.81 | SIRT6 (0.46) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL17056469 | 0.81 | SIRT6 (0.40) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL11905335 | 0.81 | SIRT6 (0.46) | MAPTSIRT6FAAHMGLLALDH1A1 | |
| SCHEMBL16103935 | 0.81 | SIRT6 (0.40) | MAPTSIRT6FAAHMGLLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |