Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965623 | 0.79 | BTK (0.38) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL18878390 | 0.73 | CTSL (0.39) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL23552042 | 0.72 | CTSL (0.37) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL12070311 | 0.72 | GAA (0.39) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL29395889 | 0.72 | CA1 (0.34) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL29398236 | 0.71 | CTSL (0.40) | MEN1KMT2ACTSLMAPK1CTSS | |
| SCHEMBL27936021 | 0.71 | CA12 (0.37) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL13740499 | 0.71 | CA12 (0.37) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL6888536 | 0.71 | CTSL (0.35) | MEN1KMT2AGAABTKCTSL | |
| SCHEMBL22026374 | 0.70 | MEN1 (0.38) | MEN1KMT2AGAABTKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859605-B2 | Cysteine protease inhibitors | MEDIVIR UK LTD (GB) | 2014-10-14 | — | — | US | disclosed |
| US-8815809-B2 | Cysteine protease inhibitors | MEDIVIR UK LTD (GB) | 2014-08-26 | — | — | US | disclosed |
| EP-2509956-B1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LTD (GB) | 2014-07-23 | — | — | EP | disclosed |
| WO-2011070539-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070541-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |