Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | GLA | P06280 | 1/20 | 0.71 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CD69 | Q07108 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29682135 | 0.93 | L3MBTL1 (0.80) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL340762 | 0.93 | L3MBTL1 (0.80) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| Ammonia Solution, Strong SCHEMBL28240461 | 0.91 | L3MBTL1 (0.77) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL8115884 | 0.87 | L3MBTL1 (0.71) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL21250152 | 0.85 | L3MBTL1 (0.69) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL2556136 | 0.84 | PTGDR2 (0.64) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL2559539 | 0.83 | L3MBTL1 (0.72) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL5181008 | 0.83 | L3MBTL1 (1.00) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL323801 | 0.83 | POLB (1.00) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 | |
| SCHEMBL7340039 | 0.83 | L3MBTL1 (0.63) | L3MBTL1POLBSMN1; SMN2GLAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144500-B1 | PROCESS FOR PREPARING AN EXFOLIATED, HIGH I.V. POLYMER NANOCOMPOSITE WITH AN OLIGOMER RESIN PRECURSOR AND AN ARTICLE PRODUCED THEREFROM | UNIV SOUTH CAROLINA RES FOUND (US) | 2004-06-30 | — | — | EP | disclosed |
| US-20040063841-A1 | Process for preparing an exfoliated, high I. V. polymer nanocomposite with an oligomer resin precursor and an article produced therefrom | GILMER JOHN WALKER (US) | 2004-04-01 | — | — | US | disclosed |
| US-20020193494-A1 | Process for preparing an exfoliated, high I.V. polymer nanocomposite with an oligomer resin precursor and an article produced therefrom | GILMER JOHN WALKER (US) | 2002-12-19 | — | — | US | disclosed |
| US-20020165306-A1 | Process for preparing an exfoliated, high I.V. polymer nanocomposite with an oligomer resin precursor and an article produced therefrom | EASTMAN CHEMICAL COMPANY | 2002-11-07 | — | — | US | disclosed |
| EP-1144500-A1 | PROCESS FOR PREPARING AN EXFOLIATED, HIGH I.V. POLYMER NANOCOMPOSITE WITH AN OLIGOMER RESIN PRECURSOR AND AN ARTICLE PRODUCED THEREFROM | EASTMAN CHEMICAL COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034377-A1 | PROCESS FOR PREPARING AN EXFOLIATED, HIGH I.V. POLYMER NANOCOMPOSITE WITH AN OLIGOMER RESIN PRECURSOR AND AN ARTICLE PRODUCED THEREFROM | EASTMAN CHEMICAL COMPANY (US) | 2000-06-15 | — | — | WO | disclosed |