Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30082698 | 0.85 | SIRT6 (0.53) | SIRT6NR1H2NR1H3MAPTALDH1A1 | |
| SCHEMBL24794215 | 0.85 | SIRT6 (0.53) | SIRT6NR1H2NR1H3MAPTALDH1A1 | |
| SCHEMBL30082668 | 0.85 | SIRT6 (0.53) | SIRT6NR1H2NR1H3MAPTALDH1A1 | |
| SCHEMBL24792933 | 0.85 | SIRT6 (0.53) | SIRT6NR1H2NR1H3MAPTALDH1A1 | |
| SCHEMBL16825056 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3MAPTALDH1A1LMNA | |
| SCHEMBL31104830 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3MAPTALDH1A1LMNA | |
| SCHEMBL18186364 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3MAPTALDH1A1LMNA | |
| SCHEMBL30426534 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3MAPTALDH1A1LMNA | |
| SCHEMBL31105119 | 0.84 | NR1H2 (0.50) | NR1H2NR1H3MAPTALDH1A1LMNA | |
| SCHEMBL23044905 | 0.84 | NR1H2 (0.53) | SIRT6NR1H2NR1H3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |