Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 5/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13977569 | 0.86 | CNR2 (0.49) | CNR2RAB9ACNR1RXFP1SCN9A | |
| SCHEMBL2269430 | 0.86 | CNR2 (0.51) | CNR2RAB9ACNR1RXFP1KDM4E | |
| SCHEMBL2224924 | 0.86 | CNR2 (0.51) | CNR2RAB9ACNR1RXFP1KDM4E | |
| SCHEMBL2224921 | 0.86 | CNR2 (0.51) | CNR2RAB9ACNR1RXFP1KDM4E | |
| SCHEMBL2222196 | 0.86 | CNR2 (0.51) | CNR2RAB9ACNR1RXFP1KDM4E | |
| SCHEMBL12802717 | 0.82 | CHRM1 (0.57) | ADAM17 | |
| SCHEMBL2223726 | 0.81 | CHRM1 (0.54) | CNR2CNR1ADAM17 | |
| SCHEMBL12802892 | 0.81 | CHRM1 (0.53) | ADAM17 | |
| SCHEMBL12803280 | 0.80 | CNR2 (0.43) | CNR2RAB9ACNR1SCN9A | |
| SCHEMBL12803247 | 0.80 | GABRA5 (0.47) | CNR2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |