Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.41 |
| ▸ | KIT | P10721 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688614 | 0.86 | PDGFRB (0.42) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL688901 | 0.80 | PDGFRB (0.55) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL3345929 | 0.75 | PDGFRB (0.58) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL12056525 | 0.75 | PDGFRB (0.78) | PDGFRBKITKDR | |
| SCHEMBL689002 | 0.74 | PDGFRB (0.58) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL689099 | 0.73 | PDGFRB (0.55) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL688015 | 0.72 | PDGFRB (0.59) | PDGFRBKITKDRKMT2AALDH1A1 | |
| SCHEMBL689067 | 0.72 | BRD4 (0.45) | KMT2AALDH1A1LMNABRD4 | |
| SCHEMBL688491 | 0.71 | BRD4 (0.58) | KMT2AALDH1A1POLBHTTLMNA | |
| SCHEMBL687487 | 0.71 | PDGFRB (0.59) | PDGFRBKITKDRKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123649-B1 | 3-PYRROLO-CYCLOHEXYLENE-2-DIHYDRO-INDOLINONE DERIVATIVES AND USES THEREOF | JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD (CN) | 2012-02-29 | — | — | EP | disclosed |
| US-8084621-B2 | 3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof | Jiangsu Simcere Pharmaceutical R&D Co. Ltd. (CN) | 2011-12-27 | — | — | US | disclosed |
| US-20100160318-A1 | 3-Pyrrolo[b]Cyclohexylene-2-Dihydroindolinone Derivatives and Uses Thereof | JIANGSU SIMCERE PHARMACEUTICAL R&D CO., LTD. (CN) | 2010-06-24 | — | — | US | disclosed |
| EP-2123649-A1 | 3-PYRROLO-CYCLOHEXYLENE-2-DIHYDRO-INDOLINONE DERIVATIVES AND USES THEREOF | Jiangsu Simcere Pharmaceutical R&D Co., Ltd. (CN) | 2009-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160318-A1 | 3-Pyrrolo[b]Cyclohexylene-2-Dihydroindolinone Derivatives and Uses Thereof | PTK2B, DMPK, STK25 | PDGFRB 504/4885KIT 324/4885KDR 665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.