Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | F2 | P00734 | 5/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188554 | 0.90 | F2 (0.36) | SMN1; SMN2LMNAF2F10PRSS2 | |
| SCHEMBL6888564 | 0.88 | NPC1 (0.39) | USP2SMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL6884082 | 0.87 | ALDH1A1 (0.37) | TSHRMAPTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL6749445 | 0.80 | F2 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1KMT2AF2 | |
| Hydrochloric Acid SCHEMBL7928497 | 0.80 | F2 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1KMT2AF2 | |
| SCHEMBL7931212 | 0.77 | F2 (0.40) | SMN1; SMN2LMNAF2F10PRSS2 | |
| SCHEMBL6888647 | 0.76 | F2 (0.39) | SMN1; SMN2LMNAMEN1KMT2AF2 | |
| SCHEMBL6752905 | 0.76 | F2 (0.41) | F2F10PRSS2 | |
| SCHEMBL6747439 | 0.76 | F2 (0.41) | F2F10PRSS2 | |
| Hydrochloric Acid SCHEMBL7934197 | 0.76 | F2 (0.41) | F2F10PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730783-B2 | REACTING AMINOGUANIDINE WITH CARBONYL COMPOUND TO FORM AMIDINOHYDRAZONE; REDUCTION; REACTING WITH ALKOXYAMINE; GUANIDINYLATION; ANTICOAGULANTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2004-05-04 | — | — | US | disclosed |
| US-6638931-B1 | Aminoguanidines and alkoxyguanidines as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2003-10-28 | — | — | US | disclosed |
| US-6235778-B1 | ANTICOAGULANTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2001-05-22 | — | — | US | disclosed |