Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274855 | 0.85 | NR1H4 (0.64) | NR1H4LMNATP53 | |
| SCHEMBL274019 | 0.77 | NR1H4 (0.65) | NR1H4LMNATP53 | |
| SCHEMBL274128 | 0.76 | NR1H4 (0.66) | NR1H4 | |
| SCHEMBL273791 | 0.72 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL278965 | 0.68 | NR1H4 (0.85) | NR1H4 | |
| SCHEMBL5732372 | 0.68 | NR1H4 (0.49) | NR1H4LMNATRPV1 | |
| SCHEMBL688979 | 0.67 | NR1H4 (0.47) | NR1H4LMNATP53 | |
| SCHEMBL275154 | 0.67 | NR1H4 (0.62) | NR1H4LMNA | |
| SCHEMBL275517 | 0.67 | NR1H4 (0.71) | NR1H4 | |
| SCHEMBL687797 | 0.67 | NR1H4 (0.46) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | claimed |