Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893522 | 0.90 | ESR1 (0.40) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL27600065 | 0.89 | SMN1; SMN2 (0.42) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL6897495 | 0.89 | ESR1 (0.39) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL3949257 | 0.86 | ESR1 (0.40) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL27600066 | 0.86 | ESR1 (0.37) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL1625434 | 0.83 | PDE10A (0.47) | TP53MAPTTAAR1NTRK1NTRK2 | |
| SCHEMBL1625492 | 0.81 | TAAR1 (0.41) | ESR1ESR2TP53MAPTKMT2A | |
| SCHEMBL1625247 | 0.81 | TAAR1 (0.41) | ESR1ESR2TP53MAPTTAAR1 | |
| SCHEMBL1625725 | 0.80 | TP53 (0.49) | ESR1ESR2SMN1; SMN2TP53MAPT | |
| SCHEMBL1623811 | 0.80 | JAK2 (0.56) | TP53MAPTCRBNMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6710054-B2 | CONTAINING SULFONYLAMINOCARBONYL GROUPS; PROSTAGLANDIN INHIBITORS | PFIZER INC | 2004-03-23 | — | — | US | disclosed |