Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891914 | 0.82 | BACE1 (0.71) | BACE1KCNH2BACE2 | |
| SCHEMBL932073 | 0.74 | BACE1 (0.59) | BACE1KCNH2BACE2 | |
| SCHEMBL6891103 | 0.70 | BACE1 (0.56) | BACE1KCNH2BACE2 | |
| SCHEMBL6892665 | 0.69 | BACE1 (0.80) | BACE1KCNH2BACE2 | |
| SCHEMBL4707325 | 0.68 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL6894615 | 0.68 | BACE1 (0.73) | BACE1KCNH2BACE2 | |
| SCHEMBL943175 | 0.68 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL931835 | 0.68 | BACE1 (1.00) | BACE1KCNH2BACE2 | |
| SCHEMBL13649187 | 0.66 | HRH3 (0.60) | BCL2 | |
| SCHEMBL932581 | 0.66 | BACE1 (0.92) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |