Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | NOTCH1 | P46531 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932073 | 0.86 | BACE1 (0.59) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932230 | 0.80 | BACE1 (0.59) | BACE1KCNH2BACE2 | |
| SCHEMBL931281 | 0.78 | BACE1 (0.60) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932626 | 0.77 | BACE1 (0.65) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL19331170 | 0.73 | JAK2 (0.46) | BACE1GPR119NOTCH1MEN1KMT2A | |
| SCHEMBL932637 | 0.72 | BACE1 (0.86) | BACE1KCNH2BACE2 | |
| SCHEMBL19690249 | 0.72 | TSHR (0.46) | BACE1GPR119MEN1KMT2A | |
| SCHEMBL19331220 | 0.71 | TSHR (0.48) | BACE1GPR119NOTCH1MEN1KMT2A | |
| SCHEMBL22156939 | 0.71 | GPR119 (0.49) | GPR119 | |
| SCHEMBL1427529 | 0.70 | NAMPT (0.53) | GPR119NOTCH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |