Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890126 | 0.91 | MTOR (0.49) | MTORRPTORMLST8HTR2BJAK2 | |
| SCHEMBL6893589 | 0.88 | MTOR (0.47) | MTORRPTORMLST8HTR2BJAK2 | |
| SCHEMBL6894512 | 0.86 | MTOR (0.48) | MTORRPTORMLST8HTR2BJAK2 | |
| SCHEMBL1023287 | 0.84 | MTOR (0.53) | MTORRPTORMLST8JAK2JAK1 | |
| SCHEMBL16104570 | 0.84 | MTOR (0.51) | MTORRPTORMLST8 | |
| SCHEMBL1073657 | 0.84 | MTOR (0.51) | MTORRPTORMLST8 | |
| SCHEMBL6892718 | 0.83 | MTOR (0.51) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL6890659 | 0.82 | MTOR (0.52) | MTORRPTORMLST8JAK1CHEK1 | |
| SCHEMBL10254689 | 0.82 | MTOR (0.47) | MTORRPTORMLST8CHEK1CCNA2 | |
| SCHEMBL10239910 | 0.81 | MTOR (0.41) | MTORRPTORMLST8CHEK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |