Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6891287 | 0.91 | MTOR (0.48) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL6894512 | 0.88 | MTOR (0.48) | MTORRPTORMLST8JAK1JAK2 | |
| SCHEMBL6893589 | 0.87 | MTOR (0.47) | MTORRPTORMLST8JAK1JAK2 | |
| SCHEMBL6891641 | 0.87 | PIK3CD (0.41) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL1023287 | 0.87 | MTOR (0.53) | MTORRPTORMLST8JAK1JAK2 | |
| SCHEMBL6891435 | 0.86 | MTOR (0.44) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL16104566 | 0.85 | MTOR (0.49) | MTORRPTORMLST8JAK1ACACB | |
| SCHEMBL16104570 | 0.84 | MTOR (0.51) | MTORRPTORMLST8 | |
| SCHEMBL1073657 | 0.84 | MTOR (0.51) | MTORRPTORMLST8 | |
| SCHEMBL6892718 | 0.84 | MTOR (0.51) | MTORRPTORMLST8CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |