Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.49 |
| ▸ | METAP1 | P53582 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253384 | 0.76 | BCHE (0.49) | LMNAALDH1A1 | |
| SCHEMBL5578427 | 0.75 | METAP2 (0.52) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL7610450 | 0.74 | METAP2 (0.47) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL7610434 | 0.74 | METAP2 (0.47) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL7610441 | 0.74 | METAP2 (0.47) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL7612959 | 0.73 | METAP2 (0.49) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL7612965 | 0.73 | METAP2 (0.49) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL4888894 | 0.70 | CYP2C9 (0.50) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL4888890 | 0.70 | CYP2C9 (0.50) | METAP2METAP1EPHX2LMNAGAA | |
| SCHEMBL4888902 | 0.70 | CYP2C9 (0.50) | METAP2METAP1EPHX2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |