Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2329373 | 0.80 | MAPT (0.44) | ESR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3031033 | 0.80 | ESR2 (0.57) | ESR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL165222 | 0.80 | ALDH1A1 (0.45) | ESR2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13469678 | 0.77 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28822221 | 0.77 | MAPT (0.46) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL13280281 | 0.74 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL29191227 | 0.74 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28881300 | 0.73 | ALDH1A1 (0.39) | MAPTRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10290660 | 0.73 | MAPT (0.43) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL849880 | 0.72 | POLB (0.41) | MAPTNPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |