Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831448 | 0.90 | HPGD (0.51) | TOP2ASMN1; SMN2MAPTALDH1A1ALOX15 | |
| SCHEMBL14929541 | 0.88 | SMN1; SMN2 (0.57) | TOP2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL9830208 | 0.88 | ALDH1A1 (0.51) | TOP2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL27943015 | 0.86 | MAPT (0.58) | SMN1; SMN2MAPTALDH1A1ALOX15TSHR | |
| SCHEMBL4826633 | 0.84 | TOP2A (0.45) | TOP2ASMN1; SMN2MAPTALDH1A1ALOX15 | |
| SCHEMBL16302283 | 0.83 | TOP2A (0.48) | TOP2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL9830217 | 0.81 | MAPT (0.55) | TOP2AMAPTALDH1A1POLBTSHR | |
| SCHEMBL13196370 | 0.80 | TOP2A (0.49) | TOP2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL658049 | 0.80 | MAPT (0.59) | TOP2ASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL9830974 | 0.80 | TOP2A (0.46) | TOP2ASMN1; SMN2MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073339-A1 | BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-06-23 | — | — | WO | disclosed |