Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | RXRB | P28702 | 6/20 | 0.57 |
| ▸ | RXRG | P48443 | 6/20 | 0.57 |
| ▸ | RARB | P10826 | 6/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.57 |
| ▸ | RARG | P13631 | 5/20 | 0.57 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15961496 | 0.87 | RXRA (0.67) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5540268 | 0.86 | RXRA (0.66) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5540299 | 0.85 | RXRA (0.69) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7889455 | 0.84 | RXRA (0.61) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5534931 | 0.82 | RXRA (0.72) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4532789 | 0.81 | RXRA (0.71) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL727916 | 0.81 | RXRA (0.70) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6890868 | 0.81 | RXRA (0.79) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6890302 | 0.80 | RXRA (0.69) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22560751 | 0.78 | RXRA (0.81) | RXRAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006157-A2 | RXR AGONIST COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2011-01-13 | — | — | WO | disclosed |