Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP10 | P09238 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222716 | 0.91 | CHRM1 (0.52) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL6890080 | 0.87 | BRD4 (0.47) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2223735 | 0.84 | CHRM1 (0.51) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL12803162 | 0.82 | CHRM1 (0.53) | ADAM17CHRM1 | |
| SCHEMBL2223674 | 0.80 | CHRM1 (0.54) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL6891498 | 0.80 | CHRM1 (0.50) | CHRM1 | |
| SCHEMBL2223323 | 0.80 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2363404 | 0.80 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL2223326 | 0.80 | CHRM1 (0.56) | ADAM17MMP3MMP7MMP10CHRM1 | |
| SCHEMBL6893085 | 0.79 | CHRM1 (0.55) | ADAM17MMP3MMP7MMP10CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |