Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP10 | P09238 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892030 | 0.88 | CHRM1 (0.52) | BRD4CHRM1NPC1RAB9AGABRA5 | |
| SCHEMBL2222716 | 0.87 | CHRM1 (0.52) | CHRM1MMP3MMP7MMP10ADAM17 | |
| SCHEMBL6892555 | 0.87 | ADAM17 (0.46) | CHRM1MMP3MMP7MMP10ADAM17 | |
| SCHEMBL12803162 | 0.83 | CHRM1 (0.53) | CHRM1ADAM17 | |
| SCHEMBL6891432 | 0.81 | CHRM1 (0.51) | BRD4CHRM1RAB9AGABRA5MAPK1 | |
| SCHEMBL12958877 | 0.80 | ALOX15 (0.53) | NPC1LMNA | |
| SCHEMBL6890113 | 0.80 | CHRM1 (0.49) | BRD4CHRM1RAB9ALMNAMAPK1 | |
| SCHEMBL2223735 | 0.80 | CHRM1 (0.51) | CHRM1MMP3MMP7MMP10ADAM17 | |
| SCHEMBL2275591 | 0.79 | CHRM1 (0.53) | BRD4CHRM1 | |
| SCHEMBL21935353 | 0.77 | CHRM1 (0.47) | BRD4CHRM1NPC1RAB9AGABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |