Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | DPP4 | P27487 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6893856 | 1.00 | GRM2 (0.61) | GRM2MAP4K4DPP4JAK3BTK | |
| SCHEMBL6893180 | 0.86 | GRM2 (0.59) | GRM2 | |
| SCHEMBL6890122 | 0.81 | GRM2 (0.69) | GRM2 | |
| SCHEMBL16264307 | 0.80 | GRM2 (0.56) | GRM2 | |
| SCHEMBL6891879 | 0.80 | GRM2 (0.60) | GRM2 | |
| SCHEMBL6891411 | 0.80 | GRM2 (0.60) | GRM2 | |
| SCHEMBL6891800 | 0.79 | GRM2 (0.63) | GRM2 | |
| SCHEMBL6892975 | 0.78 | GRM2 (0.70) | GRM2 | |
| SCHEMBL1502986 | 0.78 | GRM2 (0.67) | GRM2MAP4K4 | |
| SCHEMBL1503021 | 0.77 | GRM2 (0.63) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |