Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890122 | 0.88 | GRM2 (0.69) | GRM2CYP3A4 | |
| SCHEMBL6891830 | 0.84 | GRM2 (0.45) | GRM2SHMT2ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL1502983 | 0.81 | GRM2 (0.65) | GRM2CYP3A4 | |
| Hydrochloric Acid SCHEMBL1502962 | 0.81 | GRM2 (0.59) | GRM2CYP3A4 | |
| SCHEMBL6893152 | 0.79 | GRM2 (0.61) | GRM2 | |
| SCHEMBL1503074 | 0.79 | GRM2 (0.63) | GRM2CYP3A4 | |
| SCHEMBL1502967 | 0.78 | GRM2 (1.00) | GRM2 | |
| SCHEMBL6893180 | 0.78 | GRM2 (0.59) | GRM2CYP3A4 | |
| SCHEMBL6891474 | 0.76 | GRM2 (0.62) | GRM2CYP3A4 | |
| SCHEMBL6894419 | 0.76 | GRM2 (0.83) | GRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011034741-A1 | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-24 | — | — | WO | disclosed |