Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | EIF4A1 | P60842 | 5/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13807710 | 0.83 | KDM4E (0.41) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL4602833 | 0.76 | KDM4E (0.52) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL13793603 | 0.75 | MCHR1 (0.51) | MEN1KMT2ADHODHTP53 | |
| SCHEMBL7507266 | 0.72 | KDM4E (0.70) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL42477 | 0.71 | DHODH (0.81) | KDM4EMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL29788461 | 0.71 | DHODH (0.81) | KDM4EMEN1KMT2ASMN1; SMN2DHODH | |
| SCHEMBL10355755 | 0.69 | PPARA (0.59) | KDM4E | |
| SCHEMBL9867556 | 0.69 | MEN1 (0.69) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL14398158 | 0.68 | PPARA (0.69) | SMN1; SMN2HSD17B10POLB | |
| SCHEMBL9866680 | 0.67 | KDM4E (0.58) | KDM4EMEN1KMT2ASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040082079-A1 | Low affinity screening method | GRAFFINITY PHARMACEUTICALS AG. (DE) | 2004-04-29 | — | — | US | disclosed |
| EP-1360489-A1 | LOW AFFINITY SCREENING METHOD | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002063299-A1 | LOW AFFINITY SCREENING METHOD | GRAFFINITY PHARMACEUTICALS AG (DE) | 2002-08-15 | — | — | WO | disclosed |