Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.71 |
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
| ▸ | HTT | P42858 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11105710 | 0.86 | HTT (0.73) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL11161561 | 0.86 | HTT (0.73) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL7830678 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL28322852 | 0.81 | ALDH1A1 (0.70) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL11101107 | 0.81 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL1672017 | 0.81 | HTT (1.00) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL11281364 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL11102744 | 0.79 | ALDH1A1 (0.78) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL1591313 | 0.79 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTSMN1; SMN2GAA | |
| SCHEMBL1591316 | 0.79 | ALDH1A1 (0.67) | ALDH1A1LMNAHTTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126833-A4 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1126833-A2 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025768-A1 | OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | TREGA BIOSCIENCES, INC. (US) | 2000-05-11 | — | — | WO | disclosed |