SCHEMBL6895117

SCHEMBL6895117

Cc1ccc(C)c(-c2cc(F)c(O)c(F)c2)c1-c1cc(F)c(O)c(F)c1

nearest known ligand 0.45

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RPS6KA3 P51812 8/20 0.45
VRK1 Q99986 2/20 0.44
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
ERN1 O75460 1/20 0.38
HSD17B1 P14061 2/20 0.38
HSD17B2 P37059 2/20 0.38
NISCH Q9Y2I1 1/20 0.37
TSHR P16473 1/20 0.37
CASP1 P29466 1/20 0.37
AKR1C2 P52895 1/20 0.36
AKR1C1 Q04828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8420067 0.81 RPS6KA3 (0.46) RPS6KA3VRK1HSD17B1HSD17B2
SCHEMBL6889137 0.78 ESR1 (0.48) ESR1ESR2ERN1HSD17B1HSD17B2
SCHEMBL833139 0.74 ESR1 (0.56) RPS6KA3VRK1ESR1ESR2CA1
SCHEMBL19390583 0.72 VRK1 (0.53) RPS6KA3VRK1ESR1ESR2ERN1
SCHEMBL16982130 0.71 ESR1 (0.41) RPS6KA3VRK1ESR1ESR2ERN1
SCHEMBL16982145 0.71 ESR2 (0.50) RPS6KA3VRK1ESR1ESR2CA1
SCHEMBL5528708 0.71 CA1 (0.54) CA1CA2HSD17B1HSD17B2TSHR
SCHEMBL14087817 0.70 NQO1 (0.61) RPS6KA3VRK1ESR1ESR2CA1
SCHEMBL13446770 0.70 RPS6KA3 (0.58) RPS6KA3VRK1ESR1ESR2
SCHEMBL129716 0.69 SELL (0.58) RPS6KA3VRK1ESR1ESR2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040191602-A1 Crosslinkable aromatic resin having protonic acid group, and ion conductive polymer membrane, binder and fuel cell using the resin MITSUI CHEMICALS, INC. (JP) 2004-09-30 US disclosed