Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669 | 0.81 | TERT (0.64) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL6778831 | 0.80 | TERT (0.50) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL6356953 | 0.79 | TERT (0.57) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL6778371 | 0.78 | TERT (0.41) | TERTNR3C1PDE5A | |
| SCHEMBL6359187 | 0.78 | CSF1R (0.36) | TERTLMNAMAPTL3MBTL1NR3C1 | |
| SCHEMBL30357138 | 0.75 | TERT (0.65) | TERTRAB9ANPC1LMNAMAPT | |
| SCHEMBL1792 | 0.75 | TERT (0.65) | TERTRAB9ANPC1LMNAMAPT | |
| SCHEMBL12317587 | 0.75 | PDE5A (0.36) | TERTPDE5A | |
| SCHEMBL1705329 | 0.75 | TERT (0.61) | TERTSMN1; SMN2RAB9ANPC1LMNA | |
| SCHEMBL4856945 | 0.75 | TERT (0.54) | TERTSMN1; SMN2RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |