Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486894 | 0.78 | NPC1 (0.67) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL1680284 | 0.74 | LMNA (0.64) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL9749106 | 0.73 | PLK1 (0.73) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL11962154 | 0.73 | PLK1 (1.00) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL29738314 | 0.71 | HDAC1 (0.62) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL15844989 | 0.71 | HDAC1 (0.62) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL13844834 | 0.71 | PLK1 (0.74) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL31419202 | 0.70 | PLK1 (0.72) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL3492806 | 0.70 | PLK1 (0.72) | RAB9ANPC1CASP3SENP8SENP7 | |
| SCHEMBL31306420 | 0.70 | NPC1 (0.59) | RAB9ANPC1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809113-B2 | FOR THERAPY OF ARTHRITIS, ASTHMA, ATHEROSCLEROSIS, DIABETIC NEPHROPATHY, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, MULTIPLE SCLEROSIS, NEPHRITIS, PANCREATITIS, PULMONARY FIBROSIS, PSORIASIS, RESTENOSIS TRANSPLANT REJECTION | TELIK, INC. | 2004-10-26 | — | — | US | disclosed |