Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.31 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12227898 | 0.98 | ALDH1A1 (0.40) | ALDH1A1HCRTR2NPC1EPHX1CARM1 | |
| Ammonia Solution, Strong SCHEMBL8083171 | 0.87 | NPC1 (0.43) | ALDH1A1NPC1EPHX1SHBGCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8078526 | 0.87 | NPC1 (0.43) | ALDH1A1NPC1EPHX1SHBGCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8076859 | 0.87 | NPC1 (0.43) | ALDH1A1NPC1EPHX1SHBGCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8078237 | 0.87 | NPC1 (0.43) | ALDH1A1NPC1EPHX1SHBGCYP1A2 | |
| Ammonia Solution, Strong SCHEMBL8076640 | 0.87 | NPC1 (0.43) | ALDH1A1NPC1EPHX1SHBGCYP1A2 | |
| SCHEMBL10486140 | 0.87 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL10486147 | 0.87 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL60435 | 0.85 | — | — | |
| SCHEMBL5150085 | 0.85 | NPC1 (0.44) | ALDH1A1NPC1EPHX1SHBGCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904438-B1 | DICYCLOALKYLCARBAMOYL UREAS AS GLUCOKINASE ACTIVATORS | NOVO NORDISK AS (DK) | 2012-02-29 | — | — | EP | disclosed |
| US-7999114-B2 | Dicycloalkylcarbamoyl ureas as glucokinase activators | NOVO NORDISK A/S (DK) | 2011-08-16 | — | — | US | disclosed |
| US-20080319028-A1 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators | NOVO NORDISK A/S (DK) | 2008-12-25 | — | — | US | disclosed |
| EP-1904438-A1 | DICYCLOALKYLCARBAMOYL UREAS AS GLUCOKINASE ACTIVATORS | Novo Nordisk A/S (DK) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006761-A1 | DICYCLOALKYLCARBAMOYL UREAS AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319028-A1 | Dicycloalkylcarbamoyl Ureas As Glucokinase Activators | GCK, HK1, GCKR | ALDH1A1 2374/4885HCRTR2 4242/4885NPC1 1545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.