Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.49 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901985 | 1.00 | ATM (0.51) | ATMCYP1A2ADRB2ADRB1ADRB3 | |
| SCHEMBL3901991 | 1.00 | ATM (0.51) | ATMCYP1A2ADRB2ADRB1ADRB3 | |
| SCHEMBL3347686 | 0.86 | BACE1 (0.50) | BACE1SLC6A11BCHE | |
| SCHEMBL3347692 | 0.86 | BACE1 (0.50) | BACE1SLC6A11BCHE | |
| SCHEMBL3357521 | 0.84 | BACE1 (0.48) | BACE1SLC6A11BCHE | |
| SCHEMBL3351374 | 0.84 | BCHE (0.48) | BACE1SLC6A11BCHEKDM4E | |
| SCHEMBL3357526 | 0.84 | BACE1 (0.48) | BACE1SLC6A11BCHE | |
| SCHEMBL3351369 | 0.84 | BCHE (0.48) | BACE1SLC6A11BCHEKDM4E | |
| SCHEMBL7051379 | 0.84 | BCHE (0.48) | BACE1SLC6A11BCHEKDM4E | |
| SCHEMBL7306846 | 0.84 | BACE1 (0.60) | BACE1SLC6A11BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004502669-A | — | — | 2004-01-29 | — | — | JP | claimed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | claimed |