Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 7/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.60 |
| ▸ | CA6 | P23280 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL6896510 | 1.00 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL14483709 | 0.91 | KDM4E (0.50) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL7776900 | 0.85 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Thiosalicylic Acid SCHEMBL11202067 | 0.85 | MAPT (0.66) | ALDH1A1KDM4EPTGS1SLC7A11TDP1 | |
| Salicylic Acid SCHEMBL28318137 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Cysteine SCHEMBL8640367 | 0.82 | PTGS1 (0.52) | ALDH1A1CA12CA1CA2CA4 | |
| Dl-Phenylalanine SCHEMBL28650247 | 0.82 | SLC7A5 (0.71) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Cysteine SCHEMBL8640370 | 0.82 | PTGS1 (0.52) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL8411467 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EHPGDCA12CA1 | |
| SCHEMBL10824784 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EHPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429807-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA Pharma AG (DE) | 2004-06-23 | — | — | EP | claimed |
| WO-2003024489-A2 | COMBINATION OF A NSAID AND A PDE-4 INHIBITOR | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | claimed |
| EP-0936899-A4 | COSMETIC COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-02 | — | — | EP | claimed |
| US-6267978-B1 | COSMETIC FOR REGULATION OF THE OILY AND/OR SHINY APPEARANCE OF SKIN | THE PROCTER & GAMBLE COMPANY | 2001-07-31 | — | — | US | claimed |
| US-6143310-A | WATER IN OIL EMULSION CONTAINING AMINO ACID SALT OF SALICYLIC ACID | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-07 | — | — | US | claimed |
| EP-0936899-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1998010741-A1 | COSMETIC COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-19 | — | — | WO | claimed |