Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896740 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3KDM1AKMT2A | |
| SCHEMBL2719923 | 0.81 | KDM1A (0.54) | KDM1AKMT2APOLBHPGDL3MBTL1 | |
| SCHEMBL2830909 | 0.78 | L3MBTL1 (0.58) | KDM1AKMT2APOLBHPGDL3MBTL1 | |
| SCHEMBL5863472 | 0.77 | L3MBTL1 (0.60) | KDM1AKMT2APOLBHPGDL3MBTL1 | |
| SCHEMBL2094368 | 0.75 | KDM1A (0.46) | KDM1AKMT2APOLBHPGDL3MBTL1 | |
| SCHEMBL4208468 | 0.75 | SOS1 (0.48) | KMT2APOLBL3MBTL1 | |
| SCHEMBL239923 | 0.73 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KDM1AKMT2A | |
| SCHEMBL605459 | 0.73 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KDM1AKMT2A | |
| SCHEMBL4766363 | 0.73 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3KDM1AKMT2A | |
| SCHEMBL12120364 | 0.73 | KCNH2 (0.45) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379510-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070494-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2002-09-12 | — | — | WO | disclosed |