Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 2/20 | 0.30 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 3/20 | 0.30 |
| ▸ | HCK | P08631 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280112 | 0.86 | PIK3CA (0.35) | BRD4CREBBPPIK3CAEGFRFGFR2 | |
| SCHEMBL6891825 | 0.83 | BRD4 (0.37) | BRD4CREBBPPIK3CAEGFRFGFR2 | |
| SCHEMBL6894421 | 0.83 | BRD4 (0.40) | BRD4CREBBPPIK3CAEGFRFGFR2 | |
| SCHEMBL584020 | 0.78 | CHRNB2 (0.43) | NISCHMEN1NPC1RAB9AKMT2A | |
| SCHEMBL10280107 | 0.77 | PIK3CA (0.36) | BRD4CREBBPPIK3CAEGFRFGFR2 | |
| SCHEMBL6894944 | 0.75 | CDK8 (0.42) | BRD4CREBBPPIK3CAATRATRIP | |
| SCHEMBL6893490 | 0.74 | CRBN (0.42) | BRD4CREBBPPIK3CA | |
| SCHEMBL595712 | 0.74 | NPC1 (0.43) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6893405 | 0.74 | EGFR (0.35) | BRD4CREBBPPIK3CAEGFRFGFR2 | |
| SCHEMBL6894398 | 0.73 | BRD4 (0.38) | BRD4CREBBPPIK3CAEGFRFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MERCK SHARP & DOHME LLC | 2012-05-10 | — | — | US | disclosed |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, PSEN1 | BRD4 1555/4885CREBBP 1744/4885PIK3CA 2681/4885 |
| US-20120114739-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | MTOR, RICTOR, RPTOR | BRD4 1117/4885CREBBP 612/4885PIK3CA 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.