Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.60 |
| ▸ | GNMT | Q14749 | 1/20 | 0.57 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.55 |
| ▸ | GAPDH | P04406 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.55 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.55 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896932 | 1.00 | ADORA2A (0.60) | ADORA2AADORA2BADORA1ADORA3GNMT | |
| SCHEMBL6896781 | 0.89 | ADORA2A (0.65) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL6896787 | 0.89 | ADORA2A (0.65) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL6898295 | 0.85 | ADORA2A (0.63) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL6898304 | 0.85 | ADORA2A (0.63) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL5980045 | 0.83 | ADORA3 (0.69) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL5980036 | 0.83 | ADORA3 (0.69) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL14425024 | 0.83 | ADORA3 (0.69) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL6896076 | 0.81 | ADORA1 (0.66) | ADORA2AADORA2BADORA1ADORA3DPP4 | |
| SCHEMBL6896080 | 0.81 | ADORA1 (0.66) | ADORA2AADORA2BADORA1ADORA3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604409-B1 | OLIGONUCLEOTIDE ANALOGS FOR DETECTING AND MODULATING RNA ACTIVITY AND GENE EXPRESSION | ISIS PHARMACEUTICALS INC (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1418179-A2 | Compositions and methods for detecting and modulating rna activity and gene expression | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6262241-B1 | ANTISENSE COMPOUNDS WHICH CLEAVE PHOSPHORODIESTER BONDS AND IMPROVE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF OLIGONUCLEOTIDES, USEFUL IN DIAGNOSING DISEASES | ISIS PHARMACEUTICALS, INC. | 2001-07-17 | — | — | US | disclosed |