Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24282441 | 0.86 | — | — | |
| SCHEMBL5094102 | 0.74 | KCNA5 (0.35) | KCNA5 | |
| SCHEMBL10930996 | 0.74 | KCNA5 (0.35) | KCNA5 | |
| SCHEMBL866759 | 0.72 | PKN1 (0.47) | MAOAMAOBCYP2A6PKN1PKN2 | |
| SCHEMBL21305078 | 0.70 | MAP2K1 (0.61) | MAP2K1MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL30927658 | 0.70 | MAP2K1 (0.37) | MAP2K1IDO1 | |
| SCHEMBL6327678 | 0.69 | KCNA5 (0.48) | KCNA5KMT2AL3MBTL1MEN1MAPK1 | |
| SCHEMBL6327679 | 0.69 | KCNA5 (0.48) | KCNA5KMT2AL3MBTL1MEN1MAPK1 | |
| SCHEMBL980230 | 0.68 | MAP2K1 (0.58) | MAP2K1PKN1PKN2PRKCIDYRK1A | |
| SCHEMBL13482127 | 0.68 | PKN1 (0.44) | MAOAMAOBCYP2A6PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707774-A | Bromination method of microwave-assisted 1,5,6, 7-tetrahydro-4H-indol-4-one derivative | 浙江工业大学 | 2025-03-28 | — | — | CN | claimed |
| US-20230219890-A1 | BICYCLIC COMPOUNDS AND USE THEREOF | BETTA PHARMACEUTICALS CO LTD (CN) | 2023-07-13 | — | — | US | claimed |
| CN-115916748-A | Indole derivatives as alpha-1 antitrypsin modulators for the treatment of alpha-1 antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-110003187-B | Polyfluoroalkyl substituted benzofuran compound and preparation method thereof | 南京工业大学 | 2021-11-05 | — | — | CN | claimed |
| CN-101195600-B | Method for producing 4-hydroxyindole | CHANGZHOU SUNLIGHT FINE CHEMICALS CO LTD | 2012-06-20 | — | — | CN | claimed |
| EP-2069325-A2 | ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES | Serenex, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008024977-A2 | ISOQUINOLINE, QUINAZOLINE AND PHTHALAZINE DERIVATIVES | SERENEX, INC. (US) | 2008-02-28 | — | — | WO | claimed |
| US-6002018-A | N-substituted 4-hydroxyindoline derivatives | L'OREAL (FR) | 1999-12-14 | — | — | US | claimed |
| US-5869692-A | COUPLER FOR OXIDATION COLOR DYEING OF HAIR | L'OREAL (FR) | 1999-02-09 | — | — | US | claimed |
| EP-0754681-B1 | N-substituted 4-hydroxyindole derivatives and compositions for dyeing keratinous fibers containing them | OREAL (FR) | 1998-03-04 | — | — | EP | claimed |
| EP-0780118-B1 | Compositions for dyeing keratinous fibers containing N-substituted 4-hydroxy indoline derivatives, and certain of these derivatives | OREAL (FR) | 1997-12-29 | — | — | EP | claimed |
| US-5618982-A | SIMPLE INDUSTRIAL PROCESS OF CATALYZING IN PRESENCE OF METALLIC PHOSPHATES | RHONE-POULENC CHIMIE (FR) | 1997-04-08 | — | — | US | claimed |
| EP-0101004-B2 | PROCESS FOR PREPARING 4-OXO-4, 5, 6, 7-TETRAHYDROINDOLE DERIVATIVE | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-10-16 | — | — | EP | claimed |
| US-4824965-A | 4-oxo-4,5,6,7-Tetrahydroindole derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1989-04-25 | — | — | US | claimed |
| EP-0101004-B1 | PROCESS FOR PREPARING 4-OXO-4, 5, 6, 7-TETRAHYDROINDOLE DERIVATIVE | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1987-01-21 | — | — | EP | claimed |
| EP-0081137-B1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES, THEIR USE AS INTERMEDIATES, AND 4-HYDROXY INDOLES | Roche Diagnostics GmbH (DE) | 1986-08-06 | — | — | EP | claimed |
| EP-0101004-A1 | Process for preparing 4-oxo-4, 5, 6, 7-tetrahydroindole derivative | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1984-02-22 | — | — | EP | claimed |
| JP-56103160-A | — | — | None | — | — | JP | disclosed |
| JP-S56115744-A | NITROBENZENE DERIVATIVE AND ITS PREPARATION | YAMAMOTO KAGAKU KOGYO KK | 1981-09-11 | — | — | JP | disclosed |
| JP-S56103160-A | PRODUCTION OF 4-HYDROXYINDOLE | SEITETSU KAGAKU CO LTD | 1981-08-18 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219890-A1 | BICYCLIC COMPOUNDS AND USE THEREOF | CYP11B2, CYP11B1, CYP1B1 | MAP2K1 4086/4885MAOA 238/4885MAOB 125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.