Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5110866 | 0.86 | CYP2C19 (0.50) | ALOX15TSHRHTTSCN9ARARG | |
| SCHEMBL689665 | 0.82 | MAPT (0.41) | HTTRARGRXRAPPARGPOLB | |
| SCHEMBL5118633 | 0.81 | BCHE (0.39) | HTTHSP90AA1HSP90AB1SCN9AACHE | |
| SCHEMBL690623 | 0.80 | RARG (0.41) | HPGDTSHRHTTRARGRXRA | |
| SCHEMBL5117060 | 0.78 | MEN1 (0.37) | HTTRARGRXRAPPARGKDM4E | |
| SCHEMBL688392 | 0.77 | MAPK14 (0.38) | HTTRARGRXRAPPARGKDM4E | |
| SCHEMBL1848243 | 0.77 | HPGD (0.43) | PKMALOX15HPGDTSHRRAB9A | |
| SCHEMBL689659 | 0.76 | RARG (0.35) | HTTRARGRXRAPPARGPOLB | |
| SCHEMBL5110256 | 0.75 | SLC6A4 (0.42) | ALOX15HTTSCN9AALDH1A1MEN1 | |
| SCHEMBL5118350 | 0.74 | POLB (0.42) | ALOX15TSHRHTTACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |