Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 5/20 | 0.35 |
| ▸ | SYK | P43405 | 5/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16106451 | 0.83 | MAPK14 (0.50) | GSK3AMAPK14HTTMEN1KMT2A | |
| SCHEMBL16829471 | 0.80 | GSK3A (0.49) | GSK3AMAPK14SRCSYK | |
| SCHEMBL16829458 | 0.79 | MAPK14 (0.50) | GSK3AMAPK14HTTMEN1KMT2A | |
| SCHEMBL16829249 | 0.79 | MAPK14 (0.50) | GSK3AMAPK14HTTMEN1KMT2A | |
| SCHEMBL16829221 | 0.79 | MAPK14 (0.50) | GSK3AMAPK14HTTMEN1KMT2A | |
| SCHEMBL16829482 | 0.78 | MAPK14 (0.38) | GSK3AMAPK14HTTMEN1KMT2A | |
| SCHEMBL16829092 | 0.77 | MAPK14 (0.43) | HPGDTSHRRAB9AGSK3AMAPK14 | |
| SCHEMBL689738 | 0.77 | PKM (0.41) | HPGDTSHRRAB9AHTTMEN1 | |
| SCHEMBL20541046 | 0.75 | MAPK14 (0.42) | GSK3AMAPK14HTTALDH1A1MAPT | |
| SCHEMBL16829462 | 0.75 | MAPK14 (0.39) | TSHRMAPK14HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | claimed |
| WO-2010026096-A1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |