Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GNRHR | P30968 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.43 |
| ▸ | FECH | P22830 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892368 | 0.83 | CHEK1 (0.47) | KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL2033760 | 0.81 | CHRM3 (0.47) | KDM4ECHEK1CDK5CDK5R1 | |
| SCHEMBL2033423 | 0.80 | HTR2A (0.52) | KDM4ECHEK1 | |
| SCHEMBL2035842 | 0.80 | KDM4E (0.45) | KDM4ECHEK1FECHKCNH2CDK5 | |
| SCHEMBL2033685 | 0.80 | CHEK1 (0.53) | KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL2033544 | 0.79 | KDM4E (0.50) | KDM4ECHEK1 | |
| SCHEMBL14189551 | 0.79 | CHEK1 (0.52) | KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL304746 | 0.79 | CHEK1 (0.52) | KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL304745 | 0.79 | CHEK1 (0.52) | KDM4ECHEK1FECHKCNH2 | |
| SCHEMBL12643386 | 0.79 | CHEK1 (0.59) | KDM4ECHEK1FECHKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379510-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070494-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2002-09-12 | — | — | WO | disclosed |