Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2036696 | 0.88 | KDM4E (0.72) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2037030 | 0.85 | KDM4E (0.51) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2035469 | 0.85 | KDM4E (0.51) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2034352 | 0.85 | KDM4E (0.51) | CHEK1KDM4ERAB9AHRH3NPC1 | |
| SCHEMBL2033544 | 0.84 | KDM4E (0.50) | CHEK1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2037643 | 0.84 | KDM4E (0.55) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL12643387 | 0.84 | RAB9A (0.48) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2033423 | 0.82 | HTR2A (0.52) | CHEK1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2036678 | 0.82 | KDM4E (0.51) | CHEK1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL2034063 | 0.82 | PKM (0.61) | CHEK1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379510-B1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHEMOSENSITIZERS | ICOS CORP (US) | 2011-06-01 | — | — | EP | disclosed |