Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16519791 | 0.87 | HCRTR2 (0.49) | MAP3K14HCRTR2TAAR1CHEK1 | |
| SCHEMBL13834604 | 0.80 | MAP3K14 (0.53) | MAP3K14LTB4RLTB4R2TAAR1CHEK1 | |
| SCHEMBL6897674 | 0.80 | AKR1B1 (0.38) | HCRTR2LTB4RLTB4R2HTR2C | |
| SCHEMBL1981577 | 0.80 | MAP3K14 (0.53) | MAP3K14LTB4RLTB4R2TAAR1CHEK1 | |
| SCHEMBL1981575 | 0.80 | MAP3K14 (0.53) | MAP3K14LTB4RLTB4R2TAAR1CHEK1 | |
| SCHEMBL6900318 | 0.80 | MAP3K14 (0.53) | MAP3K14LTB4RLTB4R2TAAR1CHEK1 | |
| SCHEMBL12533501 | 0.79 | MAP3K14 (0.69) | MAP3K14HCRTR2LTB4RLTB4R2TAAR1 | |
| SCHEMBL10159264 | 0.79 | MAP3K14 (0.50) | MAP3K14HCRTR2TAAR1HTR2C | |
| SCHEMBL23505795 | 0.75 | LTB4R (0.46) | HCRTR2LTB4RLTB4R2 | |
| SCHEMBL13117923 | 0.75 | LTB4R (0.46) | HCRTR2LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509950-B1 | 5-Amino-4-hydroxypentoyl amides | JANSSEN R & D IRELAND (IE) | 2015-02-25 | — | — | EP | disclosed |
| WO-2011070131-A1 | 5-AMINO- 4-HYDROXYPENTOYL AMIDES | TIBOTEC PHARMACEUTICALS (IE) | 2011-06-16 | — | — | WO | disclosed |