Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | GABRE | P78334 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667904 | 0.88 | SLC22A6 (0.43) | SLC22A6TDP1ALDH1A1LMNAMAPT | |
| SCHEMBL1408567 | 0.77 | MMP12 (0.32) | SLC22A6TDP1ALDH1A1LMNAMAPT | |
| SCHEMBL868750 | 0.76 | — | — | |
| SCHEMBL9035264 | 0.76 | BLM (0.41) | SLC22A6TDP1ALDH1A1LMNAMAPT | |
| SCHEMBL20966262 | 0.75 | — | — | |
| SCHEMBL98745 | 0.75 | — | — | |
| SCHEMBL8612540 | 0.75 | — | — | |
| SCHEMBL2811956 | 0.74 | SLC22A6 (0.50) | SLC22A6TDP1ALDH1A1LMNAMAPT | |
| SCHEMBL27558335 | 0.74 | KDM4C (0.43) | LMNACACNA2D1RNPEPCACNB3CACNA1C | |
| SCHEMBL3515609 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910362-B1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PROD INC (US) | 2004-10-27 | — | — | EP | claimed |
| CN-1110302-C | Oxa acids and related compounds for treating skin conditions | AVON PROD INC (US) | 2003-06-04 | — | — | CN | claimed |
| US-6534543-B2 | Topical compositions with carboxy acid/ester, amide, or thioester/thioacid groups, with one or more of ether, amine, or sulfide groups; for example 3,6-dioxaheptanioic acid; peeling skin, softening hair | AVON PRODUCTS, INC. | 2003-03-18 | — | — | US | claimed |
| US-20020040056-A1 | Oxa acids and related compounds for treating skin conditions | AVON PRODUCTS, INC. | 2002-04-04 | — | — | US | claimed |
| JP-2000511900-A | — | — | 2000-09-12 | — | — | JP | claimed |
| US-6071962-A | IN TOPICAL APPLICATIONS TO TREAT VARIOUS SKIN CONDITIONS ATTRIBUTED TO, ACCOMPANIED BY OR EXACERBATED BY ABNORMAL DESQUAMATION INCLUDING DRY SKIN, ICHTHYOSIS, PALMAR AND PLANTAR HYPERKERATOSES, DANDRUFF, LICHEN SIMPLEX CHRONICUS | AVON PRODUCTS, INC. (US) | 2000-06-06 | — | — | US | claimed |
| EP-0910362-A4 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PROD INC (US) | 1999-12-22 | — | — | EP | claimed |
| CN-1221342-A | Oxo acids and related compounds for the treatment of skin conditions | AVON PROD INC (US) | 1999-06-30 | — | — | CN | claimed |
| EP-0910362-A1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PRODUCTS, INC. (US) | 1999-04-28 | — | — | EP | claimed |
| WO-1997046231-A1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PRODUCTS, INC. (US) | 1997-12-11 | — | — | WO | claimed |
| EP-0910362-B1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PROD INC (US) | 2004-10-27 | — | — | EP | disclosed |
| US-6534543-B2 | Topical compositions with carboxy acid/ester, amide, or thioester/thioacid groups, with one or more of ether, amine, or sulfide groups; for example 3,6-dioxaheptanioic acid; peeling skin, softening hair | AVON PRODUCTS, INC. | 2003-03-18 | — | — | US | disclosed |
| US-20020040056-A1 | Oxa acids and related compounds for treating skin conditions | AVON PRODUCTS, INC. | 2002-04-04 | — | — | US | disclosed |
| US-6333356-B1 | TOPICAL COMPOUNDS FOR SKIN DISORDERS | AVON PRODUCTS, INC. | 2001-12-25 | — | — | US | disclosed |
| US-6071962-A | IN TOPICAL APPLICATIONS TO TREAT VARIOUS SKIN CONDITIONS ATTRIBUTED TO, ACCOMPANIED BY OR EXACERBATED BY ABNORMAL DESQUAMATION INCLUDING DRY SKIN, ICHTHYOSIS, PALMAR AND PLANTAR HYPERKERATOSES, DANDRUFF, LICHEN SIMPLEX CHRONICUS | AVON PRODUCTS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-6069169-A | OXA acids and related compounds for treating skin conditions | AVON PRODUCTS, INC. (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0910362-A4 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PROD INC (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0910362-A1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PRODUCTS, INC. (US) | 1999-04-28 | — | — | EP | disclosed |
| WO-1997046231-A1 | OXA ACIDS AND RELATED COMPOUNDS FOR TREATING SKIN CONDITIONS | AVON PRODUCTS, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040056-A1 | Oxa acids and related compounds for treating skin conditions | OXGR1, OXA1L, CXCR1 | SLC22A6 1020/4885TDP1 2847/4885ALDH1A1 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.